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Final Program

684 - Outcomes of Matrix-Associated Autologous Chondrocyte Implantation (MACI) for Ankle Osteochondral Lesions: A Systematic Review

Friday, February 28, 2025
5:00 PM - 6:30 PM MST

    Co-Author(s)

  • JW

    Jimmy Wen, BA

    Medical Student
    California Northstate University College of Medicine
    Elk Grove, California, United States

    • Presenting Author(s)

  • BS

    Burhaan Syed, BS

    Medical Student
    California Northstate University College of Medicine
    Elk Grove, California, United States

    • Co-Author(s)

  • UA

    Ubaid Ansari, BS

    Medical Student
    California Northstate University College of Medicine
    Elk Grove, California, United States

  • VT

    Vince Thomas, BS

    Medical Student
    California Northstate University College of Medicine
    Elk Grove, California, United States

  • MS

    Mouhamad Shehabat, BS

    Medical Student
    California Northstate University College of Medicine
    Elk Grove, California, United States

  • MA

    Muzammil Akhtar, BS

    Medical Student
    California Northstate University College of Medicine
    Elk Grove, California, United States

  • DR

    Daniel Razick, BS

    Medical Student
    California Northstate University College of Medicine
    Elk Grove, California, United States

    • Corresponding Author(s)

  • CK

    Christopher Kreulen, MD

    Professor of Clinical Orthopaedic Surgery
    UC Davis Department of Orthopaedic Surgery
    Sacramento, California, United States

Objectives: Osteochondral lesions of the talus (OLT) are difficult to address due to the limited intrinsic healing capacity of cartilage. Matrix-Associated Autologous Chondrocyte Implantation (MACI) has emerged as a promising treatment through harvesting and culturing autologous chondrocytes to implant into the defect site. The purpose of this systematic review is to analyze studies reporting outcomes after MACI for OLTs through evaluation of patient-reported outcomes (PROs) and rates of complications.

Design:

A search following the guidelines established by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was performed in three databases for studies including MACI repair for OLTs. Study variables included title, author, publication date, study year, number of patients/ankles, mean age, mean follow-up time, return to activity/sport, PROs, and rates of complications.

Results: 11 studies including 166 MACI patients with an age range of 17.7 to 45.8 years, defect size range of 1.21 to 3.4 cm2, and follow-up time of 21.1 to 144 months were included. The mean preoperative ranges for American Orthopedic Foot and Ankle Score  (AOFAS) (9 studies) and Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) (1 study) were 36.9 to 70.1 and 62.4 respectively. The mean postoperative ranges for AOFAS (9 studies) and MOCART (4 studies) were 78.3 to 95.3 and 62 to 83.8, respectively. The overall rate of complications (9 studies/149 patients) was 21.5% (32) and revisions were 16.8% (25).

Conclusions:

MACI is a viable technique for addressing osteochondral lesions of the talus with short- and mid-term follow-up demonstrating excellent functional scores and PROs with low rates of complications.