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876 - Sitting Reduction and Blood Pressure in Adults with Cardiovascular Disease

Friday, February 28, 2025

5:00 PM - 6:30 PM MST

Presenting Author(s)

OA

Ovuokerie Addoh, MD

Asst Professor
University of Washington
Seattle, Washington, United States
NB

Nicole R. Bennington-McKay, BA

Medical Student
University of Washington School of Medicine
Seattle, Washington, United States
NB

Nitin Bajaj, DO, MS

Resident Physician
University of Washington
Seattle, Washington, United States

Co-Author(s)

WZ

Weiwei Zhu, MS

Biostatistician
Kaier Permanente Washington Research Institute
Seattle, Washington, United States
LH

Laura B. Harrington, PhD, MPH

Assistant Investigator
Kaiser Permanente Washington Health Research Institute
Seattle, Washington, United States
DR

Dori Rosenberg, PhD, MPH

Senior Investigator
Kaiser Permanente Washington Health Research Institute
Seattle, Washington, United States

Objectives: Sedentary time reductions may improve blood pressure. This study explores whether the association between a sitting reduction intervention and the outcomes of sitting time and systolic blood pressure differed by cardiovascular disease (CVD) history.

Design: The Healthy Aging Resources to Thrive (HART) parallel group randomized clinical trial included adults 60-89 years with high sitting time and body mass index (BMI) 30-50kg/m2. Intervention group (“I-STAND”) participants received 10 coaching sessions with personalized sitting reduction goals, standing desk, fitness tracker, and sitting time feedback. Control group participants received 10 coaching sessions on general health goals excluding physical activity or sedentary behavior. Outcomes were activPAL accelerometer-measured sitting time and systolic blood pressure. Multivariable linear regression models examined the difference in adjusted mean change between the I-STAND versus Control for the outcomes; the p-value accompanying an interaction between CVD history and the intervention group tested for CVD moderation.

Results: Among 283 participants (140 intervention, 143 control), mean [SD] age was 68.8 [6.2] years, mean [SD] BMI was 34.9kg/m2 [4.7], 65.7% were female and 51.9% had hypertension. While there was no significant moderation evidence(p=0.24), patterns suggested that participants with CVD had greater sitting time reductions with a difference in adjusted mean change of -53.39mins/day (95% CI -96.66. to -10.12mins/day) compared to those without CVD (-22.25mins/day, 95% CI -49.53 to 5.04mins/day), favoring the intervention. Those with CVD had a trend towards (p=0.06) improvements in systolic blood pressure (-8.61mmHg, 95% CI -14.79, -2.42) compared to those without CVD (-1.62mmHg, 95% CI -5.53, 2.28), favoring the intervention.

Conclusions: Adults with CVD reduced sitting time and systolic blood pressure equivalently, or better than, those without CVD suggesting a target for future rehabilitation interventions.